If reductionism is like trying to stuff all of reality into a box, we could say the problem is that the box is always too small. Idols deify some part of the created order. But no matter which part they choose, a part is always too limited to explain the whole. The universe is too complex and multi-dimensional to fit into a box composed of just one part. Invariably something will stick out. Something will not fit into its restricted conceptual categories.
The Christian admits that the universe is manifold and even miscellaneous, just as a sane man knows that he is complex. The sane man knows that he has a touch of the beast, a touch of the devil, a touch of the saint, a touch of the citizen. Nay, the really sane man knows that he has a touch of the madman. But the materialist’s world is quite simple and solid, just as the mad-man is quite sure he is sane. The materialist is sure that history has been simply and solely a chain of causation . . . Materialists and madmen never have doubts.